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KMID : 1188320150090050657
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Gut and Liver
2015 Volume.9 No. 5 p.657 ~ p.664
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Hepatitis B Surface Antigen Quantification across Different Phases of Chronic Hepatitis B Virus Infection Using an Immunoradiometric Assay
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Jung Kwang-Hyun
Kim Won
Kim Byeong-Gwan
Lee Ho-Young
Jin Eun-Hyo
Cho Yu-Ri
Seo Ji-Yeon
Kim Hwi-Young
Jung Yong-Jin
Kim Ji-Won
Jeong Ji-Bong
Lee Kook-Lae
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Abstract
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Background/Aims:Quantification of hepatitis B surface antigen (HBsAg) is an emerging serologic test and may be useful for identifying treatment strategies for chronic hepatitis B (CHB). This study aimed to evaluate HBsAg titers during the natural course of CHB and identify correlations between HBsAg titers and hepatitis B virus (HBV) DNA concentrations across different CHB phases measured using an immunoradiometric assay (IRMA).
Methods:CHB phases were defined on the basis of HBV DNA concentrations, the presence of hepatitis B e antigen/antibody (HBeAg/Ab) and serum alanine aminotransferase levels. Serum HBsAg titers and paired HBV DNA concentrations in the different phases of CHB were compared using 627 serum samples.
Results:Mean HBsAg titers were significantly higher in the immunotolerant (IT) phase and immunoreactive (IR) HBeAg-positive phase than in the low-replicative (LR) and HBeAg-negative CHB (ENH) states. The correlation between HBsAg titers and HBV DNA concentrations was modest in the IT (n=36, r=0.804, p<0.001) and IR (n=48, r=0.773, p<0.001) phases, and it was poor in the LR state (n=116, r=0.289, p=0.002); however, no significant correlation was observed in the ENH state (n=67, r=0.146, p=0.237) or in the oral nucleos(t)ide analogue-treated group (n=267).
Conclusions:HBsAg quantification using IRMA might be useful for discriminating different CHB phases and different stages of chronic liver disease.
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KEYWORD
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Hepatitis B virus, Hepatitis B surface antigens, Immunoradiometric assay, DNA
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